Research Needs Rodent Models of Restless Legs Syndrome, But Assessing RLS in...
The International Restless Legs Syndrome Study Group publishes a new guideline on construct validity of rodent models of RLS. By Jane Kollmer How do you know if a mouse has restless legs syndrome?...
View ArticleCDC Changes Opioid Prescribing Guidelines
The 2022 CDC Opioid Prescribing Guidelines released on November 3, 2022, replaced earlier guidelines that had led to confusion, misinterpretation, and faulty application by medical providers,...
View ArticleAccuracy of Restless Legs Syndrome Screening Questionnaires Questioned
For epidemiological studies, screening instruments used to diagnose restless legs syndrome in the absence of clinical interviews aren’t cutting it, experts say. By Risa Kerslake, BSN-RN An...
View ArticleFDA Grants De Novo Status for Wearable System to Treat RLS
The US Food and Drug Administration (FDA) has granted Noctrix Health its De Novo request for the NTX100 Tonic Motor Activation System to treat symptoms of moderate to severe restless legs syndrome...
View ArticleMCRA Helps Noctrix Secure Marketing Authorization for RLS Therapy Device
MCRA LLC, a medical device-focused regulatory advisory firm and clinical research organization, assisted Noctrix Health in obtaining marketing authorization via a De Novo Request from the US Food and...
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How to Reduce Augmentation Risk in Restless Legs Syndrome
Physicians who regularly manage RLS patients offer real-world advice on ways to prevent augmentation. For patients already experiencing augmentation, new therapy options may be on the way. By Alyx...
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Restless Legs Syndrome Biomarker Could Be Hiding in Periodic Limb Movements...
A meta-analysis identifies a potential polysomnographic signal of RLS more sensitive and specific than the PLMS index. Interview by Alyx Arnett A new meta-analysis refines the understanding of...
View ArticleWearable RLS Therapy Offers Respite to Drug-Refractory Patients, Studies Show
Noctrix Health Inc’s wearable TOMAC therapy for the treatment of restless legs syndrome (RLS) was found to be safe and effective, providing a “substantial reduction” in symptoms, for adult patients...
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How to Diagnose Restless Legs Syndrome Across Ages
Communication challenges can complicate the diagnosis of RLS. Sleep experts navigate these complexities from childhood to senior years, using customized questions and strategies. By Alyx Arnett...
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Anxiety Drug Pregabalin Linked to Rising Number of Deaths – Here’s What You...
By Ian Hamilton, University of York and Harry Sumnall, Liverpool John Moores University There has been a significant rise in deaths linked to the commonly prescribed anxiety drug, pregabalin. While in...
View ArticleGenetic Clues Unlock Mysteries of Restless Legs Syndrome
Researchers identify over 140 new genetic risk factors, providing insights into potential treatments for this common condition. Summary: A study has identified over 140 new genetic risk factors for...
View Article13% of Americans Diagnosed with Restless Legs Syndrome: Survey
Restless legs syndrome can lead to poor sleep, daytime sleepiness, and higher risks of depression and anxiety. Summary: A survey from the American Academy of Sleep Medicine found that 13% of Americans...
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AASM and RLS Foundations Join Forces to Drive RLS Research
The AASM Foundation and RLS Foundation have partnered to co-fund research aimed at uncovering new treatments and advancing a potential cure for restless legs syndrome. Summary: The American Academy of...
View ArticleAASM’s New RLS Guidelines Recommend Peroneal Nerve Stimulation Therapy
The new guidelines recognize high-frequency peroneal nerve stimulation as an effective, non-pharmacologic option for reducing symptom severity in patients with restless legs syndrome. Summary: The...
View ArticleNew AASM Guidelines Overhaul Restless Legs Syndrome Treatment
The updated guideline emphasizes iron evaluation and supplementation while recommending against the use of dopamine agonists due to risks of symptom worsening. Summary: The American Academy of Sleep...
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An RLS Prescription Revolution May Have Begun
The AASM updates its clinical guideline for restless legs syndrome. It recommends against the most popular drugs. By Alyx Arnett Dopamine agonists make up three of the four US Food and Drug...
View ArticleRestless Legs Syndrome Is Incurable – Here’s How to Manage the Symptoms
Adam Taylor, Lancaster University Restless legs syndrome (RLS), also known as Willis-Ekbom Disease, is a neurological condition that affects about 7% of people. Typical symptoms include an...
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Restless Legs Syndrome Research Reaches Its Stride
Christopher Earley, MBBCh, PhD, has moved our understanding of restless legs syndrome forward, in particular the condition’s relationship to iron and dopamine. By Lisa Spear | Photography by Brian...
View ArticleWhy I Evaluate My Neuropathy Patients for Restless Legs Syndrome
New research finds that small fiber neuropathy is linked with RLS and has a significant impact on quality of life. By Lisa Spear If neurologists don’t evaluate neuropathy patients for restless legs...
View ArticleAre Dopamine Agonists Doing More Harm Than Good for Restless Legs Syndrome...
A new study finds about 20% of restless legs syndrome patients are prescribed doses above the recommended maximum. By Lisa Spear Prescribers might feel confident in bumping up the dose of dopaminergic...
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